bone graft, xenogeneic bone, xenogenic bone, xenograft, bone xenograft, bovine bone, rabbit implantatio, rabbit femur, rabbit condyle, critical size defect, T650, hydroxyapatite, hydroxylapatite, in vivo study, bone subsitute, bone biomaterial, HAP, critical defect, critical size, autograft, histomorphometry, Laddec, Lubboc

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Purified xenogeneic bone used as a bone substitute (I) : comparison of the healing of bone defects filled with autograft, hydroxylapatite or a xenogeneic graft (T650). An in vivo study in the rabbit femoral condyle.
Biomed. Res. 6, 211-222, 1995


Bone grafts are becoming increasingly common in orthopedics, neurosurgery and parodontology. A highly purified bone graft was prepared from bovine trabecular bone (T650).Twenty-one New Zealand rabbits were used in the present study comparing several materials usable as bone substitutes. A 4.5 mm hole was drilled in the inner femoral condyle. Holes were filled with either an autograft (from the opposite condyle), an hydroxylapatite (Bioapatite ®) or T650 (Laddec ®; Lubboc ®). Animals were sacrificed at 1, 3 and 6 months after implantation and a quantitative analysis of newly-formed bone volume (BNF/IV) and remaining biomaterials (BMAT/IV) was done. In addition, some holes were left unfilled and served as controls. At 6 months, there was no tendency for spontaneous repair in the control animals. The autografted animals have repaired their trabecular mass and architecture since the first month. Hydroxylapatite appeared unresorbed at six months and only thin and scanty new trabeculæ were observed. The xenograft induced woven bone trabeculæ formation during the first month. This was associated with resorption of the material by two multinucleated cell populations. At six months, the epiphyseal architecture was restored and the biomaterial had disappeared in most cases. Xenografts appear a promising alternative to autografts and allografts, whose infectious risks should always be kept in mind.

critical size defect in a rabbit femoral bone condyle


Critical size defect in a rabbit femoral condyle: a 4mm hole was drilled six months before, there is no tendancy to restaure the trabecular bone microarchitecture. Microcomputed tomography revealed that only a limited reconstruction occurs on the margins of the hole.


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