Click on the link below to download the paper
Osteoclast count on
human bone biopsies: Why and How ?
In «Bone Morphometry», Takahashi H.E. Editeur ; Nishimura-Smith -Gordon, Niigata, London. pp 248-255 (1990).
This paper describes why osteoclast count is valuable
only when these cells have been detected histochemically
by TRAcP staining (tartrate resistant acid phosphatase). When counting osteoclasts on tissue sections using
only cytological criteria (e.e., multinucleation), one miss a large number of cells